pH Partition Hypothesis Summary Only the un-ionized form of a drug molecule passes through the intestinal membrane. Intuitively, this makes sense. Ions are highly reactive and can alter the pH of the cell. For more information, here is the original publication of the pH Partition Hypothesis. Note that the authors also assumed that their readers were edumacated in Oragen, so they didn't use the antilog notation.
Permeability of the intestinal membrane to various strengths of acids and bases
  • Weak Acids are weakly driven into the intestinal membrane
  • Strong Acids are strongly driven into the intestinal membrane
  • Weak bases are weakly driven into the intestinal membrane
  • Strong bases are strongly driven out of the intestinal membrane
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